lpetrich
Contributor
It is a "purine", chemically similar to nucleobases adenine and guanine, and it works by blocking adenosine (adenine + ribose) from a certain receptor because of its chemical resemblance. That blocking increases the production of the neurotransmitter acetylcholine, thus the stimulant effect.
It is an
Caffeine is made from guanine with a few biochemical steps, and it is made by a variety of plants.
Eudicots
- Rosids - Eurosids - Malvids
- Malvales - Malvaceae
- Theobroma cacao -- cocoa/cacao tree
- Cola spp. -- kola-nut tree
- Sapindales - Sapindaceae - Paullinia cupana -- guaraná climbing plant
- Malvales - Malvaceae
- Asterids
- Euasterids
- Lamiids - Gentianales - Rubiaceae - Coffea arabica, canephora -- coffee tree
- Campanulids - Aquifoliales - Aquifoliaceae - Ilex vomitoria (yaupon), guayusa, paraguariensis (yerba maté) -- holly tree
- Ericales - Theaceae - Camellia sinensis -- tea tree
- Euasterids
Returning to caffeine, its synthesis originated several times, widely scattered over the family tree of eudicot flowering plants.
But why might it be rare? The theory I've come up with is the
More generally, "Kill the Winner" explains biodiversity - a big success would become a victim of its success by presenting a big target for disease organisms.
"Kill the Winner" also explains the multitude of histocompatibility surface-protein variants. These proteins are used to recognize fellow cells of a multicelled organism, and a bug (general, informal sense) can fake that recognition by having a surface with a similar protein. A multitude of h-c surface proteins can limit the success of that strategy.
That has the side effect of organ-transplant rejection, but what helps us reject transplants is what keeps us from being too big a target for infectious bugs.